John Krais, who received his Ph.D. in Biomedical Engineering at OU in December of 2015 working with Dr. Roger Harrison, is now a postdoctoral fellow at the Fox Chase Cancer Center in Philadelphia. He is working with Dr. Neil Johnson in the Developmental Therapeutics Program on the study of DNA repair mechanisms and clinically relevant mutations that affect those pathways, with a specific focus on BRCA1 mutations. His aim is to study the impact of the mutant proteins within the cancer cell, investigate mechanisms of acquired resistance to current therapies, and identify potential small molecule therapeutics targeted to DNA repair pathways.
